James Van Der Beek as Dawson Leery	Creator and writer for 'The Creek', a primetime tv series which allows him to live his adolescence for a second time. Older beyond his years yet with so many more experiences to endure and life yet to live. He regularly keeps in touch with his childhood friends from Capeside, (the town where he was born), mostly with his best friend and inspiration, Joey, despite his base of operations being in LA.
Katie Holmes as Joey Potter	Book editor based in NY, but role within the company allows her to travel regularly. Dating Pacey, her long ago bantering love-to-hate target, from the days when she longed for the boy across the Creek, her best friend Dawson. A great fan and supporter of every Dawson´s work, (whose she likes to think of as her soulmate and best friend despite their turbulent romantic past), she watches "The Creek" avidly each week, calling him after each episode.
Kerr Smith as Jack McPhee	Legal guardian to late best friend Jen's daughter Amy, a precocious toddler. Shares this responsibility with boyfriend Doug, and Grams, Jack's 'surrogate' Grandmother. Dealing with his own insecurities about being a gay parent whilst helping a recently-outed Doug come to terms with his own homosexuality.
Meredith Monroe as Andie McPhee	Jack´s sister, she went through some mental illness due to a family tragedy when she was in high school. There she dated Pacey, her first love. After breaking up with Pacey and still in high school, Andie moved to Italy with a relative to fully recover from her problems. Later she came back to the States (Boston) to get her degree in medicine.
Joshua Jackson as Pacey Witter	Charming, charismatic, an absolute flirt (what has gotten him into trouble more than once), he fell in love for the first time at 16 with Andie McPhee (Jack´s sister), who left for Italy long ago, and now he´s trying for the third time to have a sucessfull relationship with Joey. Also running his own resturant, the rebuilt S.S Icehouse in Capeside, he thinks he finally has everything he has always wished for. Is that true?
Dylan Neal as Doug Witter	Sheriff of Capeside's police department and Pacey's older brother. Only since Jen's death was he able to publicly admit he was gay, but is still adjusting to telling the general public. Otherwise a reserved man, yet sensitive and responsible. Helping boyfriend Jack to raise baby Amy.
Mary Beth Piel as Evelyn 'Grams' Ryan	Jen Lindley's maternal grandmother, yet surrogate to all especially Jack, whom she took in at one stage when he most needed her. Full of faith and spirit. Diagnosed with breast cancer five years previous, but in remission for now. Living with Jack to help raise her great grand-daughter.
Arien Hoffmann as Amy Lindley McPhee	Daughter of the late Jen Lindley. A strong legacy to carry on, but not without love from all around her. Amy serves as the reminder to all who knew her mother that when you find love, keep it in your grasp and never let it go. Lives with her new father Jack, her maternal great-grandmother and occasionally Jack's boyfriend Doug.
Busy Phillips as Audrey Liddell	One of the more recent additions to the gang, Audrey has been out of everyone's lives for several years. Now she finds herself stateside again, and reconnecting with the old group again. Will old feelings between friends resurface? Only time will tell.
Wilmer Valderrama as Ethan Aguado	Spunky new hotshot book editor at Joey's company. Chameleon like, magnetic personality, confident and has no trouble with finding a date, yet shares a deprecating banter with Joey. Professional jealousy? Or something else?
Chyler Leigh as Samantha Cooper	Writer for 'The Creek' and working with Dawson on his new project. Former girlfriend of Dawson, though it didn't last. Being on her own in the world since she was very young, she´s strong, independent and not afraid of making tough decisions. She´ll be soon introduced in the wold of angst, hiden passions and conflicts that so much has marked Dawson since his teenage years